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igf-1 long r3 is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF-1 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent ( 2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body.

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